JAK-STAT経路の動的平衡が保たれていることが、免疫機能には不可欠です^1）。 JAK-STATを介したシグナル伝達が不十分だと生理的機能低下の原因となり、 過剰になると関節リウマチなどの炎症性疾患の原因となります^2）-15）。

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